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Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

Major research focus

            The major research focus from authors Wang and Ha of this paper would be the interactions between the matrix of the cell and the cell-cell from the reactors of the various types of the membrane having the extensive sought of the range used to critically analyzing the functions of a cell. Orchestrate into the organisms is then analyzed while measuring the forces such as integrins in the development of the multi-cellular cells in the Tension Gauge Tether or TGT. The molecular forces as signaling rationale techniques that immobilized sources of channels as per the workable properties of DNA are monitored through the various ligands. The peak force or tension is then found to be the 40 pN and average force would be the 12 pN in the tunable forces of adhesions for the integrin bonding of the ligands. The TGT is then used for the cue of the mechanical functionalities in the cellular forces of molecular ways of regulation as per the various receptors integrate into the Notches of the immobilized or random manner of the surface using the engagement of the ligands receptors (Wang & Ha, 2013).


            In this paper, we have analyzed the working or properties of the interactions of the matrix of the various cells and the combination with the cell-cell functions of the cellular orchestrate the range of the organisms. The bind forces in the ligand bond integrate with the receptors through using the approach of the rupturable receptors is sought out in this paper. The force of the dynamic ECM (Extra Cellular Matrix) in the lignads of the cells is analyzed through the properties of the mechanical bonding with the cells surrounded in neighbor organisms. The transmission of the forces of the mechanical intercellular interactions of the cells through the various pats in the regulating to the signals in the different directions for the processes of the adhesion is analyzed. In the small cells of the organisms proliferation through the migration strategy the core while signaling the peak tension or forces of 40 pN as tension for the growth receptors would be assist in the mechanism because the force would apply is analyzed in this paper. In the universal set of different peak range into the tunable site of tolerance strategy in the forces of tension ligands, the texture along with the framework of geometry for polarizing the mechanical properties of the cell-cell membrane of these sought of receptors (Wang & Ha, 2013).

The major experimental technique

            The figure 1 describing the principle of tension Gauge Tether (TGT) the immobilized channels for the ligands in the recepetors of the membrane would apply the force at the through the rupture of the receptors of Ttol or tolerance of the tension. The properties of the DNA as it would be aligned with the TGT while exploiting the various characteristics of dsDNA while geometrical configurations rupturing the fo4ces of antibodies applied the pairs of DNAs of 21 in numbers so that antigen correlation to the bonding would obtain through the theoretical tension of 56 pN. The senses of the cells in the matrix of the cell from the receptors of the membrane as well as cell-cell for establishing the organisms in the analytical range of the multi-cellular membranes would apply the force of the ECM. The interactions of the forces in the mechanical characteristics or properties having the tension or force of peak range such as 40 pN would be addressed through using the strategy of the adhesion alignment. The stiffness in the membrane for the mechanic- sensors active as mechanical properties for the molecular tensions for tracking the approach of the signals of the fluorescent in the TGT. The platform used in the forces of the molecular range in the single molecular density of the ligands would measure through the independent set of the TGT as rupture tension of average force of 12 pN (Wang & Ha, 2013). 

Advancement to the field

            The adhesion characteristics of the cell membrane in the matrix-cell for the TGT is channelized through the density of the multi-molecular tensions of the 54-56 pN using the RGDfk in the adhesion cells of the white cells as dots or also called as CHO-K1 indicating the values. The adhesions in the cells for the young stages or phases forming the Bovine Serum Albumin or BVM  in the DNA of the CHO-K1 membrane for fibronectin cells. The NOTCH1 that indicate the fluorescence of the H2B-YFP would cleave as the mutual unit in the configuration of the DNA. The conjugate was complementary incubated in the surface of the activation for the Notch that requires exerting no more tension such as the average force of 132 pN. 

            The tethers of 50 Ttol would apply at the level of the 53 pN for the exhibition of the fluorescence of the nuclear stemming in the cues of the mechanical properties as demonstrating the characteristics of behaviors of the cell-cell using the micro-level approach to learning the stiffness in the cell. The configuration in the regions of the Ttol for research in the integrin of the αVβ3 as well as observing the tension ranges from average to peak as 40, 43 and Ttol of 56 pN.


Wang, X., & Ha, T. (2013). Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling. Science , 340 (6135), 991–994.

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